When Chili Ncgobo, an honest but ambitious undercover cop, is cheated out of a major reward by his corrupt superiors, he infiltrates a cash-in-transit heist gang, and instead of busting them, he decides to participate in a one off score. He must face off against his partner who refuses to let him do it and one of the gang members who recognizes him as a cop.

In Johannesburg, the small time criminal Tsotsi is a teenager without feelings, hardened by his tough life. After killing a man with his gang in a robbery; hitting the gangster Boston of his gang; humiliating a crippled beggar along one night, Tsotsi hijacks a car and under the despair of a woman, he shoots her in the stomach. While driving the car, Tsotsi finds that there is a baby on the back seat and the woman was a desperate mother. He brings the baby to his house in the slum and becomes attached to him. For six days, the baby changes his behavior, arousing and developing the sense of empathy and humanity in the cold blood killer.